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A functional lncRNA HOTAIR genetic variant contributes to gastric cancer susceptibility.

Molecular carcinogenesis - 1 Jan 2016

Pan Wenting, Liu Lisheng, Wei Jinyu, Ge Yunxia, Zhang Jingfeng, Chen Hongwei, Zhou Liqing, Yuan Qipeng, Zhou Changchun, Yang Ming

Abstract excerpt

Long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) acts as an oncogene in gastric cancer development. HOTAIR could induce genome-wide retargeting of polycomb-repressive complex 2, trimethylates histone H3 lysine-27 (H3K27me3) and deregulation of multiple downstream genes. Additionally, as the ceRNA of miR-331-3p, HOTAIR may modulate HER2 deregulation in gastric cancer cells. We hypothesized that...

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PMID: 25640751
DOI: 10.1002/mc.22261

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A functional lncRNA HOTAIR genetic variant contributes to gastric cancer susceptibility.PMID 25640751Read ↗

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