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Article

Heparan sulfate proteoglycans mediate renal carcinoma metastasis.

International journal of cancer - 15 Dec 2016

Qazi Henry, Shi Zhong-Dong, Song Jonathan W, Cancel Limary M, Huang Peigen, Zeng Ye, Roberge Sylvie, Munn Lance L, Tarbell John M

Abstract excerpt

The surface proteoglycan/glycoprotein layer (glycocalyx) on tumor cells has been associated with cellular functions that can potentially enable invasion and metastasis. In addition, aggressive tumor cells with high metastatic potential have enhanced invasion rates in response to interstitial flow stimuli in vitro. Our previous studies suggest that heparan sulfate (HS) in the glycocalyx plays an important role in...

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Identifiers

PMID: 27543953
DOI: 10.1002/ijc.30397
PMCID: PMC7718768

Genes

NDST1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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