Article
Mutation analysis of IL36RN gene in Japanese patients with palmoplantar pustulosis.
The Journal of dermatology - 1 Jan 2017
Takahashi Toshifumi, Fujimoto Noriki, Kabuto Miho, Nakanishi Takeshi, Tanaka Toshihiro
Abstract excerpt
Loss-of-function mutations of the IL36RN gene, encoding interleukin-36 receptor antagonist (IL-36Ra), have been reported as major pathogenic causes of generalized pustular psoriasis (GPP), especially in cases lacking previous histories of psoriasis vulgaris. Palmoplantar pustulosis (PPP), which is traditionally included among GPP-related diseases, has a controversial association with IL36RN. While a negative view...
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