Article
Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.
Nature genetics - 1 Aug 2017
Meehan Terrence F, Conte Nathalie, West David B, Jacobsen Julius O, Mason Jeremy, Warren Jonathan, Chen Chao-Kung, Tudose Ilinca, Relac Mike, Matthews Peter, Karp Natasha, Santos Luis, Fiegel Tanja, Ring Natalie, Westerberg Henrik, Greenaway Simon, Sneddon Duncan, Morgan Hugh, Codner Gemma F, Stewart Michelle E, Brown James, Horner Neil, Haendel Melissa, Washington Nicole, Mungall Christopher J, Reynolds Corey L, Gallegos Juan, Gailus-Durner Valerie, Sorg Tania, Pavlovic Guillaume, Bower Lynette R, Moore Mark, Morse Iva, Gao Xiang, Tocchini-Valentini Glauco P, Obata Yuichi, Cho Soo Young, Seong Je Kyung, Seavitt John, Beaudet Arthur L, Dickinson Mary E, Herault Yann, Wurst Wolfgang, de Angelis Martin Hrabe, Lloyd K C Kent, Flenniken Ann M, Nutter Lauryl M J, Newbigging Susan, McKerlie Colin, Justice Monica J, Murray Stephen A, Svenson Karen L, Braun Robert E, White Jacqueline K, Bradley Allan, Flicek Paul, Wells Sara, Skarnes William C, Adams David J, Parkinson Helen, Mallon Ann-Marie, Brown Steve D M, Smedley Damian
Abstract excerpt
Although next-generation sequencing has revolutionized the ability to associate variants with human diseases, diagnostic rates and development of new therapies are still limited by a lack of knowledge of the functions and pathobiological mechanisms of most genes. To address this challenge, the International Mouse Phenotyping Consortium is creating a genome- and phenome-wide catalog of gene function by...
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