Epidermal growth factor receptor and v-Ki-ras2 Kirsten rat sarcoma viral oncogen homologue-specific amino acid substitutions are associated with different histopathological prognostic factors in resected non-small-cell lung cancer.

doi:10.1093/icvts/ivw250

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Epidermal growth factor receptor and v-Ki-ras2 Kirsten rat sarcoma viral oncogen homologue-specific amino acid substitutions are associated with different histopathological prognostic factors in resected non-small-cell lung cancer.

Interactive cardiovascular and thoracic surgery - 1 Dec 2016

Seitlinger Joseph, Renaud Stéphane, Falcoz Pierre-Emmanuel, Schaeffer Mickaël, Olland Anne, Reeb Jérémie, Santelmo Nicola, Legrain Michèle, Voegeli Anne-Claire, Weingertner Noëlle, Chenard Marie-Pierre, Beau-Faller Michèle, Massard Gilbert

Abstract excerpt

OBJECTIVES: Epidermal growth factor receptor (mEGFR) and v-Ki-ras2 Kirsten rat sarcoma viral oncogen homologue (mKRAS) mutations are the two main oncogenic drivers in resected non-small-cell lung cancer (NSCLC). We aimed to evaluate the correlation between histopathological prognostic factors and these mutations in resected NSCLC. METHODS: We retrospectively reviewed data from 841 patients who underwent a...

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PMID: 27530493
DOI: 10.1093/icvts/ivw250

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KRAS

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