Article
The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling.
Stem cell research & therapy - 17 Aug 2016
Barruet Emilie, Morales Blanca M, Lwin Wint, White Mark P, Theodoris Christina V, Kim Hannah, Urrutia Ashley, Wong Sarah Anne, Srivastava Deepak, Hsiao Edward C
Abstract excerpt
BACKGROUND: The Activin A and bone morphogenetic protein (BMP) pathways are critical regulators of the immune system and of bone formation. Inappropriate activation of these pathways, as in conditions of congenital heterotopic ossification, are thought to activate an osteogenic program in endothelial cells. However, if and how this occurs in human endothelial cells remains unclear. METHODS: We used a new directed...
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