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Article

Induced Pluripotent Stem Cells to Model Human Fibrodysplasia Ossificans Progressiva

26 Nov 2015

Abstract excerpt

Fibrodysplasia ossificans progressiva (FOP) is a rare disease characterized by progressive ossification of soft tissues, for which there is no effective treatment. Mutations in the bone morphogenetic protein (BMP) type I receptor activin receptor-like kinase 2 (ACVR1/ALK2) are the main cause of FOP. We generated human induced pluripotent stem cells (hiPSCs) from FOP patients with the ALK2 R206H mutation. The...

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PMID: 26626181
DOI: 10.1016/j.stemcr.2015.10.020

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