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Article

Epigenetic features of FoxP3 in children with cow’s milk allergy

12 Aug 2016

Abstract excerpt

BACKGROUND: DNA methylation of the Th1 and Th2 cytokine genes is altered during cow's milk allergy (CMA). Forkhead box transcription factor 3 (FoxP3) is essential for the development and function of regulatory T cells (Tregs) and is involved in oral tolerance acquisition. We assessed whether tolerance acquisition in children with IgE-mediated CMA is associated with DNA demethylation of the Treg-specific...

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PMID: 27525046
DOI: 10.1186/s13148-016-0252-z

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