Article
IDH1 mutation may not be prognostically favorable in glioblastoma when controlled for tumor location: A case-control study.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia - 1 Dec 2016
Paldor Iddo, Drummond Katharine J, Kaye Andrew H
Abstract excerpt
Isocitrate dehydrogenase 1 (IDH1) mutation is a known prognostic factor in glioblastoma multiforme (GBM). It has been well documented that patients with IDH1 mutant (IDH1-mu) GBM have a better outcome compared to patients with IDH1 wild-type (IDH1-WT) GBM. IDH1-mu tumors have been shown to be more commonly located in the frontal lobe, and less likely to be in multiple lobes. It is unclear whether differential...
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