Article

Reduced dosage of multiple dynein arm preassembly factors limits cilia regeneration in <i>Chlamydomonas reinhardtii</i>

2023-11-02

Abstract excerpt

Motile cilia are complex organelles comprised of >800 structural proteins. Variants in 58 of these genes cause primary ciliary dyskinesia (PCD) in humans. We used a second-site non-complementation approach in diploid Chlamydomonas reinhardtii strains to investigate whether reduced dosage of different combinations of motile cilia proteins affects cilia growth / regeneration. Temperature-sensitive mutants in intraf...

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Literature Corpus work: fe812f2d-09e2-5348-8456-d75c3e9fe9d9
DOI: 10.1101/2023.10.31.564885

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