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Article

Stochastic modeling suggests that noise reduces differentiation efficiency by inducing a heterogeneous drug response in glioma differentiation therapy.

BMC systems biology - 11 Aug 2016

Sun Xiaoqiang, Zhang Jiajun, Zhao Qi, Chen Xing, Zhu Wenbo, Yan Guangmei, Zhou Tianshou

Abstract excerpt

BACKGROUND: Glioma differentiation therapy is a novel strategy that has been used to induce glioma cells to differentiate into glia-like cells. Although some advances in experimental methods for exploring the molecular mechanisms involved in differentiation therapy have been made, a model-based comprehensive analysis is still needed to understand these differentiation mechanisms and improve the effects of...

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Identifiers

PMID: 27515956
DOI: 10.1186/s12918-016-0316-x
PMCID: PMC4982223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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