Article
Evaluation of Pasteurella multocida mutants of low virulence. I. Development and pathogenicity.
Avian diseases - 1 Jan 2000
Hofacre C L, Glisson J R, Kleven S H, Brown J, Rowland G N
Abstract excerpt
Mutagenesis of the Clemson University (CU) vaccine strain of Pasteurella multocida with N-methyl-N-nitro-N-nitrosoguanidine resulted in temperature-sensitive mutants that grew at 37 C but not at 42 C. Seven such mutants were evaluated for immunogenicity in turkeys. From these seven, only two, PM#1 and PM#3, provided turkeys with a level of protection against challenge with a virulent serotype 3 P. multocida...
Topics
- Animals
- Bacterial Vaccines
- Mutation
- Pasteurella
- Pasteurella Infections
- Poultry Diseases
- Temperature
- Turkeys
- Virulence