Article
Acapsular Pasteurella multocida B:2 can stimulate protective immunity against pasteurellosis.
Infection and immunity - 1 Mar 2001
Boyce J D, Adler B
Abstract excerpt
We have previously shown that a Pasteurella multocida cexA mutant (PBA875) was impaired in capsule export and highly attenuated in virulence for mice (J. D. Boyce and B. Adler, Infect. Immun. 68:3463-3468, 2000). In this study we show that immunization with high, but not low, doses of PBA875 can confer significant protection against wild-type challenge. We have also constructed a genetically defined acapsular P....
Topics
- Animals
- Bacterial Capsules
- Female
- Genes, Bacterial
- Mice
- Mice, Inbred BALB C
- Mutation
- Pasteurella Infections
- Pasteurella multocida
- Vaccination