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Article

Utility of Serial cfDNA NGS for Prospective Genomic Analysis of Patients on a Phase I Basket Study.

JCO precision oncology - 1 Jan 2021

Smyth Lillian M, Reichel Jonathan B, Tang Jiabin, Patel Juber Ahamad A, Meng Fanli, Selcuklu Duygu S, Houck-Loomis Brian, You Daoqi, Samoila Aliaksandra, Schiavon Gaia, Li Bob T, Razavi Pedram, Piscuoglio Salvatore, Reis-Filho Jorge S, Taylor Barry S, Baselga José, Solit David B, Hyman David M, Berger Michael F, Chandarlapaty Sarat

Abstract excerpt

PURPOSE: Cell-free DNA (cfDNA) analysis offers a noninvasive means to access the tumor genome. Despite limited sensitivity of broad-panel sequencing for detecting low-frequency mutations in cfDNA, it may enable more comprehensive genomic characterization in patients with sufficiently high disease burden. We investigated the utility of large-panel cfDNA sequencing in patients enrolled to a Phase I AKT1-mutant...

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Identifiers

PMID: 34250397
DOI: 10.1200/PO.20.00184
PMCID: PMC8232437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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