Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk.

doi:10.1158/1541-7786.MCR-16-0123

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Article

Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk.

Molecular cancer research : MCR - 1 Nov 2016

Pattison Jillian M, Posternak Valeriya, Cole Michael D

Abstract excerpt

It is well established that environmental toxins, such as exposure to arsenic, are risk factors in the development of urinary bladder cancer, yet recent genome-wide association studies (GWAS) provide compelling evidence that there is a strong genetic component associated with disease predisposition. A single-nucleotide polymorphism (SNP), rs8102137, was identified on chromosome 19q12, residing 6 kb upstream of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin E

Share to Enhancer Elements, Genetic

Share to Gene Expression Regulation, Neoplastic

Share to Kruppel-Like Transcription Factors

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Identifiers

PMID: 27514407
DOI: 10.1158/1541-7786.MCR-16-0123
PMCID: PMC5107141

Genes

CCNE1
KLF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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