Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Etoposide damages female germ cells in the developing ovary

15 Jul 2016

Abstract excerpt

BACKGROUND: As with many anti-cancer drugs, the topoisomerase II inhibitor etoposide is considered safe for administration to women in the second and third trimesters of pregnancy, but assessment of effects on the developing fetus have been limited. The purpose of this research was to examine the effect of etoposide on germ cells in the developing ovary. Mouse ovary tissue culture was used as the experimental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Preterm Birth and Chorioamnionitis
Share to Reproductive Biology and Fertility
Share to Reproductive System and Pregnancy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27510889
DOI: 10.1186/s12885-016-2505-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Etoposide damages female germ cells in the developing ovaryPMID 27510889Read ↗

Xenobiotic effects in the ovary: temporary versus permanent infertilitySemantic proximity Read ↗

Impact of first-line cancer treatment on the follicle quality in cryopreserved ovarian samples from girls and young womenSemantic proximity Read ↗

Germline Stem Cells and Follicular Renewal in the Postnatal Mammalian OvarySemantic proximity Read ↗

Irinotecan metabolite SN38 results in germ cell loss in the testis but not in the ovary of prepubertal miceSemantic proximity Read ↗

Sex-specific differences in fetal germ cell apoptosis induced by ionizing radiationSemantic proximity Read ↗

Dysregulation of FGFR signalling by a selective inhibitor reduces germ cell survival in human fetal gonads of both sexes and alters the somatic niche in fetal testesSemantic proximity Read ↗

Cisplatin- and cyclophosphamide-induced primordial follicle depletion is caused by direct damage to oocytesSemantic proximity Read ↗

Germ Cell Proliferation and Apoptosis in the Developing Human OvarySemantic proximity Read ↗

The immature human ovary shows loss of abnormal follicles and increasing follicle developmental competence through childhood and adolescenceSemantic proximity Read ↗

Preantral follicle culture as a novel in vitro assay in reproductive toxicology testing in mammalian oocytesSemantic proximity Read ↗

The magnitude of gonadotoxicity of chemotherapy drugs on ovarian follicles and granulosa cells varies depending upon the category of the drugs and the type of granulosa cellsSemantic proximity Read ↗

Does gonadotoxic chemotherapy deplete the ovarian reserve through activation of primordial follicles?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.