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Article

Preantral follicle culture as a novel in vitro assay in reproductive toxicology testing in mammalian oocytes

17 Dec 2003

Abstract excerpt

The most common genetic disorder in humans, trisomy, is caused predominantly by errors in chromosome segregation during oogenesis. Isolated mouse oocytes resuming meiosis and progressing to metaphase II in vitro have recently been used to assess targets, aneugenic potential and sensitivity of oocytes to chemical exposures. In order to extend in vitro maturation tests to earlier stages of oogenesis, an in vitro...

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PMID: 14681309
DOI: 10.1093/mutage/geg040

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