Article
Design and application of a target capture sequencing of exons and conserved non-coding sequences for the rat.
BMC genomics - 9 Aug 2016
Yoshihara Minako, Saito Daisuke, Sato Tetsuya, Ohara Osamu, Kuramoto Takashi, Suyama Mikita
Abstract excerpt
BACKGROUND: Target capture sequencing is an efficient approach to directly identify the causative mutations of genetic disorders. To apply this strategy to laboratory rats exhibiting various phenotypes, we developed a novel target capture probe set, TargetEC (target capture for exons and conserved non-coding sequences), which can identify mutations not only in exonic regions but also in conserved non-coding...
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