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Article

The contribution of the citrate pathway to oxidative stress in Down syndrome.

Immunology - 1 Dec 2016

Convertini Paolo, Menga Alessio, Andria Generoso, Scala Iris, Santarsiero Anna, Castiglione Morelli Maria A, Iacobazzi Vito, Infantino Vittoria

Abstract excerpt

Inflammatory conditions and oxidative stress have a crucial role in Down syndrome (DS). Emerging studies have also reported an altered lipid profile in the early stages of DS. Our previous works demonstrate that citrate pathway activation is required for oxygen radical production during inflammation. Here, we find up-regulation of the citrate pathway and down-regulation of carnitine/acylcarnitine carrier and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27502741
DOI: 10.1111/imm.12659
PMCID: PMC5095497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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