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Article

Fascin Is Critical for the Maintenance of Breast Cancer Stem Cell Pool Predominantly via the Activation of the Notch Self-Renewal Pathway.

Stem cells (Dayton, Ohio) - 1 Dec 2016

Barnawi Rayanah, Al-Khaldi Samiyah, Majed Sleiman Ghida, Sarkar Abdullah, Al-Dhfyan Abdullah, Al-Mohanna Falah, Ghebeh Hazem, Al-Alwan Monther

Abstract excerpt

An emerging dogma shows that tumors are initiated and maintained by a subpopulation of cancer cells that hijack some stem cell features and thus referred to as "cancer stem cells" (CSCs). The exact mechanism that regulates the maintenance of CSC pool remains largely unknown. Fascin is an actin-bundling protein that we have previously demonstrated to be a major regulator of breast cancer chemoresistance and...

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PMID: 27502039
DOI: 10.1002/stem.2473

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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