Article
Iron depletion-induced downregulation of N-cadherin expression inhibits invasive malignant phenotypes in human esophageal cancer.
International journal of oncology - 1 Oct 2016
Nishitani Seishi, Noma Kazuhiro, Ohara Toshiaki, Tomono Yasuko, Watanabe Shinichiro, Tazawa Hiroshi, Shirakawa Yasuhiro, Fujiwara Toshiyoshi
Abstract excerpt
Esophageal carcinomas often have a poor prognosis due to early lymph node metastasis. Epithelial-mesenchymal transition (EMT) is strongly associated with the acquisition of cancer metastasis and invasion. However, there is no established treatment to eliminate the EMT of cancer cells. Iron is an essential element for both normal and cancer cells in humans. Recently, iron depletion has been discovered to suppress...
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