Article
Folate deficient tumor microenvironment promotes epithelial-to-mesenchymal transition and cancer stem-like phenotypes.
Oncotarget - 31 May 2016
Su Yen-Hao, Huang Wen-Chien, Huang Tse-Hung, Huang Yan-Jiun, Sue Yu-Kai, Huynh Thanh-Tuan, Hsiao Michael, Liu Tsan-Zon, Wu Alexander Th, Lin Chien-Min
Abstract excerpt
Clinically, serum level of folate has been negatively correlated to the stage and progression of liver cancer. Nevertheless, the functional consequence of folate deficiency (FD) in malignancy has not been fully investigated. Human hepatocellular carcinoma (HCC) cells (as study model) and other cancer types such as lung and glioma were cultured under folate deficient (FD) and folate complete (FD) conditions....
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