Article
Structure of a Highly Active Cephalopod S-crystallin Mutant: New Molecular Evidence for Evolution from an Active Enzyme into Lens-Refractive Protein.
Scientific reports - 8 Aug 2016
Tan Wei-Hung, Cheng Shu-Chun, Liu Yu-Tung, Wu Cheng-Guo, Lin Min-Han, Chen Chiao-Che, Lin Chao-Hsiung, Chou Chi-Yuan
Abstract excerpt
Crystallins are found widely in animal lenses and have important functions due to their refractive properties. In the coleoid cephalopods, a lens with a graded refractive index provides good vision and is required for survival. Cephalopod S-crystallin is thought to have evolved from glutathione S-transferase (GST) with various homologs differentially expressed in the lens. However, there is no direct structural...
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