Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MtDNA analysis reveals enriched pathogenic mutations in Tibetan highlanders.

Scientific reports - 8 Aug 2016

Kang Longli, Zheng Hong-Xiang, Zhang Menghan, Yan Shi, Li Lei, Liu Lijun, Liu Kai, Hu Kang, Chen Feng, Ma Lifeng, Qin Zhendong, Wang Yi, Wang Xiaofeng, Jin Li

Abstract excerpt

Tibetan highlanders, including Tibetans, Monpas, Lhobas, Dengs and Sherpas, are considered highly adaptive to severe hypoxic environments. Mitochondrial DNA (mtDNA) might be important in hypoxia adaptation given its role in coding core subunits of oxidative phosphorylation. In this study, we employed 549 complete highlander mtDNA sequences (including 432 random samples) to obtain a comprehensive view of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological
Share to Asian People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Mitochondrial

Share to Evolution, Molecular

Share to Founder Effect

Share to Human Migration

Share to Mitochondria

Source

Open in PubMed Open full text

Identifiers

PMID: 27498855
DOI: 10.1038/srep31083
PMCID: PMC4976311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MtDNA analysis reveals enriched pathogenic mutations in Tibetan highlanders.PMID 27498855Read ↗

mtDNA lineage expansions in Sherpa population suggest adaptive evolution in Tibetan highlands.Semantic proximity Read ↗

Ancient mitochondrial DNA pathogenic variants putatively associated with mitochondrial disease.Semantic proximity Read ↗

Ancient mitochondrial DNA pathogenic variants putatively associated with mitochondrial diseaseSemantic proximity Read ↗

Tibetan near-complete pangenome reveals complex variants underlying high-altitude adaptationSemantic proximity Read ↗

Detecting signatures of selection within the Tibetan sheep mitochondrial genome.Semantic proximity Read ↗

Mitochondrial nt3010G-nt3970C haplotype is implicated in high-altitude adaptation of Tibetans.Semantic proximity Read ↗

Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people.Semantic proximity Read ↗

De novo assembly of a Tibetan genome and identification of novel structural variants associated with high-altitude adaptationSemantic proximity Read ↗

<i>De novo</i> assembly of a Tibetan genome and identification of novel structural variants associated with high altitude adaptationSemantic proximity Read ↗

MtDNA meta-analysis reveals both phenotype specificity and allele heterogeneity: a model for differential association.Semantic proximity Read ↗

Disease-associated mitochondrial mutations and the evolution of primate mitogenomes.Semantic proximity Read ↗

Ancient mitogenomes show plateau populations from last 5200 years partially contributed to present-day Tibetans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.