Article

Ancient mitochondrial DNA pathogenic variants putatively associated with mitochondrial disease

2020-05-13

Abstract excerpt

Mitochondrial DNA variants associated with diseases are widely studied in contemporary populations, but their prevalence has not yet been investigated in ancient populations. The publicly available AmtDB database contains 1443 ancient mtDNA Eurasian genomes from different periods. The objective of this study was to use this data to establish the presence of pathogenic mtDNA variants putatively associated with mito...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 85bfb93e-b119-5f62-858b-4cdff2ffb3a0
DOI: 10.1101/2020.05.13.094243

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ancient mitochondrial DNA pathogenic variants putatively associated with mitochondrial diseaseDOI 10.1101/2020.05.13.094243Read

Ancient mitochondrial DNA pathogenic variants putatively associated with mitochondrial disease.Semantic proximity Read

Spectrum of rare and common mitochondrial DNA variations from 1029 whole genomes of self-declared healthy individuals from India.Semantic proximity Read

The diversity present in 5140 human mitochondrial genomes.Semantic proximity Read

An unusual mitochondrial DNA sequence variant from an Egyptian mummy.Semantic proximity Read

Evidence for adaptive selection acting on the tRNA and rRNA genes of human mitochondrial DNA.Semantic proximity Read

Mitochondrial DNA in evolution and diseaseSemantic proximity Read

Probability-based sequence comparison finds pre-eutherian nuclear mitochondrial DNA segments in mammalian genomesSemantic proximity Read

Updating the East Asian mtDNA phylogeny: a prerequisite for the identification of pathogenic mutations.Semantic proximity Read

Prevalence of rare mitochondrial DNA mutations in mitochondrial disorders.Semantic proximity Read

Insights from the Analysis of Ancient and Modern DNAs with Population-specific SNPsSemantic proximity Read

MtDNA analysis reveals enriched pathogenic mutations in Tibetan highlanders.Semantic proximity Read

Disease-associated mitochondrial mutations and the evolution of primate mitogenomes.Semantic proximity Read