Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discovering the Genome-Wide Activity of CRISPR-Cas Nucleases.

ACS chemical biology - 16 Feb 2018

Tsai Shengdar Q

Abstract excerpt

Originally discovered as part of an adaptive bacterial defense system against the invasion of foreign phages, programmable CRISPR-Cas nucleases have emerged as remarkable enzymes with transformative potential for both biological research and clinical application. CRISPR-Cas nucleases likely evolved in their natural context to tolerate imperfect specificity in order to recognize mutant bacteriophages. However, in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR-Associated Proteins
Share to CRISPR-Cas Systems
Share to DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endonucleases

Share to Gene Editing

Share to Genome

Share to Mutation

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 29281250
DOI: 10.1021/acschembio.7b00847

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discovering the Genome-Wide Activity of CRISPR-Cas Nucleases.PMID 29281250Read ↗

Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity.Semantic proximity Read ↗

CRISPR-Cas Systems: Programmable Nuclease Revolutionizing the Molecular DiagnosisSemantic proximity Read ↗

Development and Application of CRISPR-Cas Based ToolsSemantic proximity Read ↗

Defining genome-wide CRISPR–Cas genome-editing nuclease activity with GUIDE-seqSemantic proximity Read ↗

The application of CRISPR/Cas9–based genome-wide screening to disease researchSemantic proximity Read ↗

CRISPR-Cas9: A Precise Approach to Genome Engineering.Semantic proximity Read ↗

CRISPR/Cas systems usher in a new era of disease treatment and diagnosisSemantic proximity Read ↗

Advances in CRISPR-Cas technology and its applications: revolutionising precision medicineSemantic proximity Read ↗

The rapidly advancing Class 2 CRISPR‐Cas technologies: A customizable toolbox for molecular manipulationsSemantic proximity Read ↗

CRISPR-Based Precision Molecular Diagnostics for Disease Detection and SurveillanceSemantic proximity Read ↗

Application of CRISPR/Cas9 for biomedical discoveriesSemantic proximity Read ↗

The Bacterial Origins of the CRISPR Genome-Editing RevolutionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.