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Modeling the prevention of colorectal cancer from the combined impact of host and behavioral risk factors

4 Aug 2016

Abstract excerpt

PURPOSE: This study investigated the utility of modeling modifiable lifestyle risk factors in addition to genetic variation in colorectal cancer (CRC) screening/prevention. METHODS: We derived a polygenic risk score for CRC susceptibility variants in combination with the established nongenetic risk factors of inflammatory bowel disease (IBD), adiposity, alcohol, red meat, fruit, vegetables, smoking, physical...

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PMID: 27490113
DOI: 10.1038/gim.2016.101

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