Article
Notch1 directly induced CD133 expression in human diffuse type gastric cancers.
Oncotarget - 30 Aug 2016
Konishi Hidetomo, Asano Naoki, Imatani Akira, Kimura Osamu, Kondo Yutaka, Jin Xiaoyi, Kanno Takeshi, Hatta Waku, Ara Nobuyuki, Asanuma Kiyotaka, Koike Tomoyuki, Shimosegawa Tooru
Abstract excerpt
CD133 is considered as a stem-like cell marker in some cancers including gastric cancers, and Notch1 signaling is known to play an important role in the maintenance and differentiation of stem-like cells. We aimed to investigate whether Notch1 signaling contributes to the carcinogenesis of gastric cancers and CD133 induction. CD133 expression was detected in 51.4% of diffuse type gastric cancers while it was not...
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