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Article

Meiotic prophase roles of Rec8 in crossover recombination and chromosome structure.

Nucleic acids research - 2 Nov 2016

Yoon Sang-Wook, Lee Min-Su, Xaver Martin, Zhang Liangran, Hong Soo-Gil, Kong Yoon-Ju, Cho Hong-Rae, Kleckner Nancy, Kim Keun P

Abstract excerpt

Rec8 is a prominent component of the meiotic prophase chromosome axis that mediates sister chromatid cohesion, homologous recombination and chromosome synapsis. Here, we explore the prophase roles of Rec8. (i) During the meiotic divisions, Rec8 phosphorylation mediates its separase-mediated cleavage. We show here that such cleavage plays no detectable role for chromosomal events of prophase. (ii) We have analyzed...

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Share to Chromosomal Proteins, Non-Histone
Share to Crossing Over, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to DNA Cleavage

Share to MAP Kinase Kinase 1

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Source

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Identifiers

PMID: 27484478
DOI: 10.1093/nar/gkw682
PMCID: PMC5100558

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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