Article
Interaction Between Rec8 and Mis4 Is Required for Axis-Loop Chromatin Formation and Homologous Chromosome Recombination During Meiosis.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Jul 2026
Sakuno Takeshi, Murayama Yasuto, Haraguchi Tokuko, Hiraoka Yasushi
Abstract excerpt
The Rec8 cohesin complex is required for the pairing and recombination of homologous chromosomes during meiosis, as well as for the cohesion of sister chromatids. In the fission yeast Schizosaccharomyces pombe, we previously identified a rec8-F204S mutant that lost the ability to assemble the axis-loop chromatin structure without losing sister chromatid cohesion. This mutant showed reduced meiotic recombination,...
Topics
- Meiosis
- Schizosaccharomyces
- Chromatin
- Schizosaccharomyces pombe Proteins
- Homologous Recombination
- Cell Cycle Proteins
- Cohesins
- Chromosomal Proteins, Non-Histone
- Mutation
- Chromatids
- Protein Binding
- Phosphoproteins