Article
The Pseudomonas aeruginosa extracellular secondary metabolite, Paerucumarin, chelates iron and is not localized to extracellular membrane vesicles.
Journal of microbiology (Seoul, Korea) - 1 Aug 2016
Qaisar Uzma, Kruczek Cassandra J, Azeem Muhammed, Javaid Nasir, Colmer-Hamood Jane A, Hamood Abdul N
Abstract excerpt
Proteins encoded by the Pseudomonas aeruginosa pvcA-D operon synthesize a novel isonitrile functionalized cumarin termed paerucumarin. The pvcA-D operon enhances the expression of the P. aeruginosa fimbrial chaperone/usher pathway (cup) genes and this effect is mediated through paerucumarin. Whether pvcA-D and/or paerucumarin affect the expression of other P. aeruginosa genes is not known. In this study, we...
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