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Article

Exploring the origin of the catalytic power and product specificity of SET domain protein methyltransferase.

Molecular bioSystems - 20 Oct 2016

Lima A H, Alves C N, Prasad R, Lameira J

Abstract excerpt

Herein, we used computer simulation to evaluate the free energy activation barriers of the first and second methyl transfer for native SET8 PKMT and its Y334F mutant. The results suggest that the origin of SET8 catalytic power is mainly due to electrostatic preorganization.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27477893
DOI: 10.1039/c6mb00414h

Genes

SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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