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Article

High EZH2 expression is correlated to metastatic disease in pediatric soft tissue sarcomas

27 Jul 2016

Abstract excerpt

BACKGROUND: Enhancer of Zeste Drosophila Homologue 2 (EZH2) is a key regulator of transcription as a member of polycomb repressive complex 2 (PRC2) which exerts repression of downstream genes and is correlated to invasiveness and progression of different tumours. Therefore, we evaluated the expression of PRC2 proteins in pediatric soft tissue sarcoma (rhabdomyosarcoma, RMS and extraosseous Ewing sarcoma, EES)...

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Share to Epigenetics and DNA Methylation
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PMID: 27471434
DOI: 10.1186/s12935-016-0338-x

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