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Article

Neurological disorders associated with DNA strand-break processing enzymes.

Mechanisms of ageing and development - 1 Jan 2017

Jiang Bingcheng, Glover J N Mark, Weinfeld Michael

Abstract excerpt

The termini of DNA strand breaks induced by reactive oxygen species or by abortive DNA metabolic intermediates require processing to enable subsequent gap filling and ligation to proceed. The three proteins, tyrosyl DNA-phosphodiesterase 1 (TDP1), aprataxin (APTX) and polynucleotide kinase/phosphatase (PNKP) each act on a discrete set of modified strand-break termini. Recently, a series of neurodegenerative and...

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Source

Open in PubMed Open full text

Identifiers

PMID: 27470939
DOI: 10.1016/j.mad.2016.07.009
PMCID: PMC5266678

Genes

APTX
PNKP
TDP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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