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Article

The melanocortin system and insulin resistance in humans: insights from a patient with complete POMC deficiency and type 1 diabetes mellitus.

International journal of obesity (2005) - 1 Jan 2014

Aslan I R, Ranadive S A, Valle I, Kollipara S, Noble J A, Vaisse C

Abstract excerpt

The central melanocortin system is essential for the regulation of long-term energy homeostasis in humans. Rodent experiments suggest that this system also affects glucose metabolism, in particular by modulating peripheral insulin sensitivity independently of its effect on adiposity. Rare patients with complete genetic defects in the central melanocortin system can provide insight into the role of this system in...

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Source

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Identifiers

PMID: 23649472
DOI: 10.1038/ijo.2013.53
PMCID: PMC4648369

Genes

POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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