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Article

Mice lacking microRNA 133a develop dynamin 2–dependent centronuclear myopathy.

The Journal of clinical investigation - 1 Aug 2011

Liu Ning, Bezprozvannaya Svetlana, Shelton John M, Frisard Madlyn I, Hulver Matthew W, McMillan Ryan P, Wu Yaru, Voelker Kevin A, Grange Robert W, Richardson James A, Bassel-Duby Rhonda, Olson Eric N

Abstract excerpt

MicroRNAs modulate cellular phenotypes by inhibiting expression of mRNA targets. In this study, we have shown that the muscle-specific microRNAs miR-133a-1 and miR-133a-2 are essential for multiple facets of skeletal muscle function and homeostasis in mice. Mice with genetic deletions of miR-133a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21737882
DOI: 10.1172/JCI46267
PMCID: PMC3148737

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21737882-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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