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Further development of the beta-lactamase MutaGen assay and evaluation by comparison with Ames fluctuation tests and the umu test.

Environmental and molecular mutagenesis - 1 Aug 2005

Reifferscheid Georg, Arndt Christian, Schmid Claudia

Abstract excerpt

A rapid, high-throughput bacterial mutagenicity test system has been developed (MutaGen test) that detects reversions of inactivating base-pair substitutions and frameshifts in a TEM-1 class A beta-lactamase (ampicillinase) gene. To quickly and sensitively detect mutagens, the system utilises a series of plasmids that contain the mutated ampicillinase gene and the mucAB operon. Inactivating mutations in the...

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PMID: 15880735
DOI: 10.1002/em.20140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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