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Mutation analysis of the PARKIN, PINK1, DJ1, and SNCA genes in Turkish early-onset Parkinson's patients and genotype-phenotype correlations.

Clinical neurology and neurosurgery - 1 Sept 2016

Erer Sevda, Egeli Unal, Zarifoglu Mehmet, Tezcan Gulcin, Cecener Gulsah, Tunca Berrin, Ak Secil, Demirdogen Elif, Kenangil Gulay, Kaleagası Hakan, Dogu Okan, Saka Esen, Elibol Bulent

Abstract excerpt

OBJECTIVE: Variations in PARK genes (PRKN, PINK1, DJ-1, and SNCA) cause early-onset Parkinson's disease (EOPD) in different populations. In the current study, we aimed to evaluate the frequencies of variations in PARK genes and the effects of these variations on the phenotypes of Turkish EOPD patients. METHODS: All coding regions and exon-intron boundaries of the PRKN, PINK1, DJ-1, and SNCA genes were screened by...

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Source

Identifiers

PMID: 27455133
DOI: 10.1016/j.clineuro.2016.07.005

Genes

PRKN
SNCA
PINK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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