Article
Rare and novel variants of PRKN and PINK1 genes in Vietnamese patients with early-onset Parkinson's disease.
Molecular genetics & genomic medicine - 1 Oct 2020
Ton Nguyen Dang, Thuan Nguyen Duc, Thuong Ma Thi Huyen, Ngoc Tran Thi Bich, Nhung Vu Phuong, Hoa Nguyen Thi Thanh, Nam Nguyen Hoai, Dung Hoang Thi, Son Nhu Dinh, Ba Nguyen Van, Bac Nguyen Duy, Tai Tran Ngoc, Dung Le Thi Kim, Hung Nguyen Trong, Duong Nguyen Thuy, Ha Nguyen Hai, Hai Nong Van
Abstract excerpt
BACKGROUND: Early-onset Parkinson's disease (EOPD) refers to that of patients who have been diagnosed or had onset of motor symptoms before age 50, accounting for 4% of Parkinson's disease patients. The PRKN and PINK1 genes, both involved in a metabolic pathway, are associated with EOPD. METHODS: To identify variants associated with EOPD, coding region of PARKIN and PINK1 genes in 112 patients and 112 healthy...
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