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Article

Mapping Variation in Cellular and Transcriptional Response to 1,25-Dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells.

PloS one - 1 Jan 2016

Kariuki Silvia N, Maranville Joseph C, Baxter Shaneen S, Jeong Choongwon, Nakagome Shigeki, Hrusch Cara L, Witonsky David B, Sperling Anne I, Di Rienzo Anna

Abstract excerpt

The active hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is an important modulator of the immune system, inhibiting cellular proliferation and regulating transcription of immune response genes. In order to characterize the genetic basis of variation in the immunomodulatory effects of 1,25D, we mapped quantitative traits of 1,25D response at both the cellular and the transcriptional level. We carried...

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Source

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Identifiers

PMID: 27454520
DOI: 10.1371/journal.pone.0159779
PMCID: PMC4959717

Genes

PAIP1
CCL28
EHD4
FRMD6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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