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Article

Vitamin D Signaling in the Context of Innate Immunity: Focus on Human Monocytes

13 Sept 2019

Abstract excerpt

The vitamin D3 metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) activates at sub-nanomolar concentrations the transcription factor vitamin D receptor (VDR). VDR is primarily involved in the control of cellular metabolism but in addition modulates processes important for immunity, such as anti-microbial defense and induction of T cell tolerance. Monocytes and their differentiated phenotypes, macrophages and...

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PMID: 31572402
DOI: 10.3389/fimmu.2019.02211

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