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Vitamin D Genomics: From In Vitro to In Vivo

23 May 2018

Abstract excerpt

The vitamin D3 metabolite α,25-dihydroxyvitamin D3 (1,25(OH)2D3) is the exclusive high-affinity ligand of the vitamin D receptor (VDR), a transcription factor with direct effects on gene expression. Transcriptome- and epigenome-wide data obtained in THP-1 human monocytes are the basis of the chromatin model of vitamin D signaling. The model describes, how VDR’s spatio-temporal binding profile provides key...

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PMID: 29875733
DOI: 10.3389/fendo.2018.00250

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