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Article

Altered fibrinolysis in autosomal dominant thrombomodulin-associated coagulopathy.

Blood - 6 Oct 2016

Burley Kate, Whyte Claire S, Westbury Sarah K, Walker Mary, Stirrups Kathleen E, Turro Ernest, Chapman Oliver G, Reilly-Stitt Christopher, Mutch Nicola J, Mumford Andrew D

Abstract excerpt

Thrombomodulin-associated coagulopathy (TM-AC) is a newly recognized dominant bleeding disorder in which a p.Cys537Stop variant in the thrombomodulin (TM) gene THBD, results in high plasma TM levels and protein C-mediated suppression of thrombin generation. Thrombin in complex with TM also activates thrombin-activatable fibrinolysis inhibitor (TAFI). However, the effect of the high plasma TM on fibrinolysis in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27436851
DOI: 10.1182/blood-2016-05-716092
PMCID: PMC5054699

Genes

THBD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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