Article
Effect of fibrinolysis on bleeding phenotype in moderate and severe von Willebrand disease.
Haemophilia : the official journal of the World Federation of Hemophilia - 1 May 2012
De Wee E M, Klaij K, Eikenboom H C J, Van Der Bom J G, Fijnvandraat K, Laros-Van Gorkom B A P, Mauser-Bunschoten E P, Meijer K, Goverde G, Van Der Linden P W G, Rijken D C, Leebeek F W G
Abstract excerpt
Patients with von Willebrand disease (VWD), the most common inherited bleeding disorder, display large variation in bleeding tendency, which is not completely related to VWF levels. The cause of variability in clinical expression is largely unknown. The effect of plasma fibrinolytic capacity on bleeding tendency in VWD patients has not been investigated. We hypothesized that enhanced fibrinolysis may result in a...
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