Article
Ibrutinib downregulates a subset of miRNA leading to upregulation of tumor suppressors and inhibition of cell proliferation in chronic lymphocytic leukemia.
Leukemia - 1 Feb 2017
Saleh L M, Wang W, Herman S E M, Saba N S, Anastas V, Barber E, Corrigan-Cummins M, Farooqui M, Sun C, Sarasua S M, Zhao Z, Abousamra N K, Elbaz O, Abdelghaffar H A, Wiestner A, Calvo K R
Abstract excerpt
The lymph node (LN) is the site of chronic lymphocytic leukemia (CLL) cell activation and proliferation. Aberrant microRNA (miRNA) expression has been shown to have a role in CLL pathogenesis; however, a comparison of miRNA expression between CLL cells in the LN and the peripheral blood (PB) has previously not been reported. On the basis of the analysis of 17 paired LN and PB samples from CLL patients, we...
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