Arabidopsis lipins mediate lipid droplet biogenesis to protect cells from lipotoxicity.

Abstract excerpt

Lipin proteins, a family of phosphatidic acid phosphatases (PAHs), are key regulators of lipid metabolism, storage, and homeostasis across eukaryotes. While Arabidopsis (Arabidopsis thaliana) lipins function in lipid biosynthesis and gene regulation, their roles in lipid droplet (LD) biogenesis and lipid homeostasis remain largely unknown. Here, we show that double knockout of two PAH genes (PAH1/2) results in...

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• Fatty Acids
• Lipid Droplets
• Lipid Metabolism
• Phosphatidate Phosphatase
• Phosphatidic Acids