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Article

Toll-like receptor 2 dominance over Toll-like receptor 4 in stressful conditions for its detrimental role in the heart.

American journal of physiology. Heart and circulatory physiology - 1 Jun 2017

Bagchi Ashim K, Akolkar Gauri, Mandal Soma, Ayyappan Prathapan, Yang Xi, Singal Pawan K

Abstract excerpt

It has been suggested that Toll-like receptor (TLR)4 promotes IL-10-mediated cardiac cell survival, whereas another receptor, TLR2, from the same family, is detrimental. Here, we examined the interactive role of these two innate signaling molecules under stressful conditions, including IL-10 knockout (IL-10-/-) mice, global ischemia-reperfusion (I/R) injury in rat hearts, and in vitro short hairpin RNA...

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Source

Identifiers

PMID: 28432060
DOI: 10.1152/ajpheart.00800.2016

Genes

TLR4
TLR2
TNF
TRAIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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