Article
An integrative in silico system for predicting dysregulated genes in the human epileptic focus: Application to SLC transporters.
Epilepsia - 1 Sept 2016
Mirza Nasir, Vasieva Olga, Appleton Richard, Burn Sasha, Carr Daniel, Crooks Daniel, du Plessis Daniel, Duncan Roderick, Farah Jibril Osman, Josan Vivek, Miyajima Fabio, Mohanraj Rajiv, Shukralla Arif, Sills Graeme J, Marson Anthony G, Pirmohamed Munir
Abstract excerpt
OBJECTIVE: Many different gene families are currently being investigated for their potential role in epilepsy and in the response to antiepileptic drugs. A common research challenge is identifying the members of a gene family that are most significantly dysregulated within the human epileptic focus, before taking them forward for resource-intensive functional studies. Published data about transcriptomic changes...
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