Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling epilepsy by loss-of-function of the CUG-binding protein Elav-like family member 2 in zebrafish with multi-omics analysis.

Chinese medical journal - 5 Feb 2026

Wang Xiaoqian, Zhang Jia, Rao Xueyi, Liu Yanyan, Lin Ziyuan, Chen Feng, Luo Rong, Sun Huaqin, Gan Jing

Abstract excerpt

BACKGROUND: The CUG-binding protein Elav-like family member 2 ( CELF2 ) gene has been linked to the pathogenesis of epilepsy, but its precise role remains unclear. This study aimed to investigate the pathogenic mechanisms of CELF2 mutation in epilepsy, utilizing zebrafish models to explore its molecular pathways and biological impact. METHODS: Whole-exome sequencing was performed to identify CELF2 mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Epilepsy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GABRG2 gene

Share to Multiomics

Share to Mutation

Share to Proteomics

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 40066778
DOI: 10.1097/CM9.0000000000003398
PMCID: PMC12875712

Genes

CELF2
BDNF
FOS
GABRA1
GABRG2
NPAS4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling epilepsy by loss-of-function of the CUG-binding protein Elav-like family member 2 in zebrafish with multi-omics analysis.PMID 40066778Read ↗

Integrative Analysis of Epilepsy-Associated Genes Reveals Expression-Phenotype CorrelationsSemantic proximity Read ↗

Integrative analysis of epilepsy-associated genes reveals expression-phenotype correlations.Semantic proximity Read ↗

Genetic variants disrupting activity-dependent CELF2 shuttling cause neuronal hyperexcitability, learning deficits, and seizuresSemantic proximity Read ↗

Phenotypic analysis of catastrophic childhood epilepsy genes: The Epilepsy Zebrafish ProjectSemantic proximity Read ↗

Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitabilitySemantic proximity Read ↗

Translation elongation factor 1A2 is encoded by one of four closely related eef1a genes and is dispensable for survival in zebrafish.Semantic proximity Read ↗

Multi-Scale Genetic and Transcriptomic Analyses Identify Druggable Targets for Epilepsy.Semantic proximity Read ↗

Transcriptomic Profiling of Zebrafish Mutant for cdkl5 Reveals Dysregulated Gene Expression Associated with Neuronal, Muscle, Visual and Skeletal DevelopmentSemantic proximity Read ↗

Translation elongation factor 1A2 (eEF1A2) is encoded by one of four closely related eef1a genes and is dispensable for survival in zebrafishSemantic proximity Read ↗

Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.Semantic proximity Read ↗

Phenotypic analysis of catastrophic childhood epilepsy genes.Semantic proximity Read ↗

De novo loss-of-function mutations in CHD2 cause a fever-sensitive myoclonic epileptic encephalopathy sharing features with Dravet syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.