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Integrative Drug-Target Causal Analysis, Single-Cell Sequencing and In-Vivo Validation for Dissecting Molecular Mechanisms Underlying Focal Epilepsy.

CNS neuroscience & therapeutics - 1 Jun 2026

Sun Huaiyu, Li Xuewei, Zhao Weixuan, Meng Hongmei, Zhang Wuqiong

Abstract excerpt

AIMS: To identify and verify new drug targets for focal epilepsy. METHODS: We combined single-cell expression data from GSE190452, with genetic data from the eQTLGen alliance and utilized expression-associated single nucleotide polymorphism as an instrumental variable in Mendelian randomization analysis to investigate the causal link between gene expression and focal epilepsy risk. Moreover, co-localization...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42295059
DOI: 10.1002/cns.70985
PMCID: PMC13267665

Genes

CASP1
FST
IL10RA
SUCNR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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